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- Scientific Committee
Professor Jerry Silver Ph.D (Case Western Reserve University, Ohio)
Jerry Silver received his PhD from Case Western Reserve in 1974 and was the recipient of the Herbert S. Steuer Memorial Award for Meritorious Original Research in Anatomy. He did post-doctoral work at Harvard University in the Department of Neurosciences at The Children’s Hospital and in the Neuropathology Department at Harvard Medical School. Jerry is currently Professor in the Department of Neurosciences at the Case Western Reserve University School of Medicine and adjunct Professor in the Department of Neurosurgery at the Cleveland Clinic Foundation. He is a recipient of several prestigious awards, he regularly reviews articles for over 35 high impact journals and he reviews grants for 18 national and international organizations. He has served on a variety of NIH study sections since 1982 including the Neurobiology Review Group, Neurology B2, The Visual Sciences C Study Section, and the Clinical Neurology, Neurotransmitters and Transplantation Study Section and has served as lead or senior author on more than 150 publications. Over the past several years, his lab has focused on the Glial-derived extracellular matrix and the inhibitory role it plays following injury. Their ultimate goal is to develop strategies to overcome inhibitory molecules and axonal dieback after injury in order to promote functional regeneration. An exciting development is their recent demonstration that combining (1) a long segment of autologous peripheral nerve as a “bridge” to bypass a hemisection lesion of the adult rat spinal cord with (2) inhibitory matrix modification via chondroitinase at the PNS/CNS interface allows regenerating axons to exit the bridge, form functional synapses, and restore useful movement to the once paralyzed limb and robust functional recovery to the diaphragm. This new strategy shows clearly, for the first time, that long distance regeneration, with appropriate re-formation of functional connections, can be achieved in the adult after spinal cord injury.